Yan Chen Selected Research

Therapeutic Uses

5/2024	Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats.
4/2024	Oroxylin A suppresses breast cancer-induced osteoclastogenesis and osteolysis as a natural RON inhibitor.
4/2024	Preclinical imaging evaluation of a bispecific antibody targeting hPD1/CTLA4 using humanized mice.
3/2024	Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction.
3/2024	A biodegradable PVA coating constructed on the surface of the implant for preventing bacterial colonization and biofilm formation.
1/2024	Anti-tumor effect and mechanism of the total biflavonoid extract from S doederleinii on human cervical cancer cells in vitro and in vivo.
1/2024	A biomimetic nanocarrier facilitates glucose consumption and reactive oxide species accumulation in enzyme therapy for colorectal cancer.
1/2024	Yanghe Pingchuan granules mitigates oxidative stress and inflammation in a bronchial asthma rat model: role of the IKK/IκB/NF-κB signalling pathway.
12/2023	Uncovering the key pharmacodynamic material basis and possible molecular mechanism of extract of Epimedium against liver cancer through a comprehensive investigation.
11/2023	[Therapeutic effect of Leonuri Herba aqueous decoction on primary dysmenorrhea in rats and its metabolomic analysis].

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Yan Chen Research Topics

Disease

701	Neoplasms (Cancer) 05/2024 - 08/2003
187	Inflammation (Inflammations) 05/2024 - 08/2003
145	Infections 07/2024 - 04/2003
118	Neoplasm Metastasis (Metastasis) 03/2024 - 05/2003
96	Breast Neoplasms (Breast Cancer) 04/2024 - 05/2007
92	Chronic Obstructive Pulmonary Disease (COPD) 12/2024 - 08/2004
88	Hepatocellular Carcinoma (Hepatoma) 04/2024 - 04/2003
86	Fibrosis (Cirrhosis) 12/2024 - 05/2007
71	Carcinogenesis 10/2023 - 04/2003
65	Hypoxia (Hypoxemia) 04/2024 - 11/2003
58	Lung Neoplasms (Lung Cancer) 12/2023 - 08/2003
55	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2024 - 09/2007
50	Leukemia 04/2024 - 04/2002
49	Carcinoma (Carcinomatosis) 10/2023 - 08/2003
48	Colorectal Neoplasms (Colorectal Cancer) 01/2024 - 02/2004
47	Body Weight (Weight, Body) 04/2024 - 01/2002
47	Stomach Neoplasms (Stomach Cancer) 03/2024 - 09/2012
45	Insulin Resistance 02/2024 - 12/2002
44	COVID-19 01/2024 - 01/2020
42	Obesity 04/2024 - 06/2008
41	Type 2 Diabetes Mellitus (MODY) 03/2024 - 09/2010
40	Asthma (Bronchial Asthma) 03/2024 - 04/2010
39	Stroke (Strokes) 12/2023 - 12/2006
34	Wounds and Injuries (Trauma) 04/2024 - 01/2006
33	Hemorrhage 01/2024 - 11/2005
33	Hypertension (High Blood Pressure) 01/2023 - 09/2009
31	Liver Neoplasms (Liver Cancer) 12/2023 - 10/2011
31	Cardiovascular Diseases (Cardiovascular Disease) 07/2023 - 01/2012
29	Emphysema 01/2024 - 08/2005
28	Rheumatoid Arthritis 03/2024 - 04/2014
28	Pain (Aches) 03/2024 - 01/2007
27	Adenocarcinoma of Lung 01/2024 - 09/2008
27	Ischemic Stroke 12/2023 - 01/2014
26	Atherosclerosis 11/2023 - 01/2007
25	Parkinson Disease (Parkinson's Disease) 05/2024 - 12/2004
25	Necrosis 02/2024 - 12/2005
24	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023 - 01/2002
23	Sepsis (Septicemia) 04/2024 - 04/2008
23	Myocardial Infarction 03/2024 - 02/2010
22	Melanoma (Melanoma, Malignant) 05/2024 - 06/2008
22	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 10/2008
22	Cognitive Dysfunction 03/2024 - 01/2015
22	Heart Failure 01/2024 - 01/2008
22	Ischemia 01/2024 - 01/2005
22	Osteoporosis 01/2024 - 12/2009
22	Adenocarcinoma 01/2024 - 08/2003
21	Uterine Cervical Neoplasms (Cancer of the Cervix) 05/2024 - 04/2003
21	Pancreatic Neoplasms (Pancreatic Cancer) 01/2024 - 02/2006
20	Multiple Myeloma 12/2024 - 10/2009

Drug/Important Bio-Agent (IBA)

297	Proteins (Proteins, Gene)FDA Link 12/2024 - 01/2002
143	Biomarkers (Surrogate Marker)IBA 05/2024 - 10/2004
96	Messenger RNA (mRNA)IBA 04/2024 - 08/2003
89	MicroRNAs (MicroRNA)IBA 04/2024 - 07/2008
76	CytokinesIBA 04/2024 - 08/2003
75	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 07/2007
54	RNA (Ribonucleic Acid)IBA 03/2024 - 06/2006
54	LipidsIBA 02/2024 - 07/2008
52	Therapeutic UsesIBA 05/2024 - 05/2007
52	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 02/2004
44	Long Noncoding RNAIBA 03/2024 - 05/2016
41	EnzymesIBA 01/2024 - 04/2002
41	SmokeIBA 01/2024 - 04/2009
37	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2024 - 01/2005
37	AntigensIBA 01/2024 - 06/2006
36	Small Interfering RNA (siRNA)IBA 05/2024 - 04/2007
36	Peptides (Polypeptides)IBA 11/2023 - 08/2003
34	VaccinesIBA 01/2024 - 07/2004
32	Interleukin-6 (Interleukin 6)IBA 04/2024 - 11/2003
30	Blood Glucose (Blood Sugar)IBA 05/2024 - 12/2010
30	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2024 - 06/2008
29	AntioxidantsIBA 04/2024 - 04/2003
28	LigandsIBA 04/2024 - 06/2003
28	Polysaccharides (Glycans)IBA 03/2024 - 11/2007
28	Cisplatin (Platino)FDA LinkGeneric 02/2024 - 09/2002
27	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2024 - 06/2003
25	CateninsIBA 12/2024 - 04/2011
25	CollagenIBA 04/2024 - 04/2004
25	Insulin (Novolin)FDA Link 03/2024 - 12/2002
25	GoldIBA 12/2023 - 03/2010
25	Triglycerides (Triacylglycerol)IBA 06/2023 - 03/2005
24	CurcuminIBA 04/2024 - 01/2002
24	Indicators and Reagents (Reagents)IBA 01/2024 - 04/2005
24	Phosphotransferases (Kinase)IBA 01/2024 - 12/2007
24	Histones (Histone)IBA 10/2023 - 09/2005
23	AlbuminsIBA 12/2023 - 06/2010
23	LipopolysaccharidesIBA 02/2023 - 04/2008
22	CreatinineIBA 01/2024 - 07/2011
22	Transcription Factors (Transcription Factor)IBA 01/2024 - 07/2011
21	Liposomes (Liposome)IBA 04/2024 - 06/2005
21	AntibodiesIBA 01/2023 - 03/2005
20	Immunoglobulin E (IgE)IBA 03/2024 - 04/2010
20	CholesterolIBA 01/2024 - 03/2005

Therapy/Procedure

368	Therapeutics 07/2024 - 06/2004
107	Drug Therapy (Chemotherapy) 03/2024 - 09/2002
53	Immunotherapy 04/2024 - 08/2002
41	Radiotherapy 02/2024 - 07/2009
34	Chinese Traditional Medicine (Traditional Chinese Medicine) 03/2024 - 01/2007
27	Transplantation 07/2023 - 08/2010
23	Aftercare (After-Treatment) 03/2024 - 01/2005
22	Length of Stay 04/2023 - 11/2008